6,297 research outputs found

    Women\u27s risk perception and sexual victimization: A review of the literature

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    This article reviews empirical and theoretical studies that examined the relationship between risk perception and sexual victimization in women. Studies examining women\u27s general perceptions of risk for sexual assault as well as their ability to identify and respond to threat in specific situations are reviewed. Theoretical discussions of the optimistic bias and cognitive–ecological models of risk recognition are discussed in order to account for findings in the literature. Implications for interventions with women as well as recommendations for future research are provided

    Gas Concentration Measurements in Underground Waste Storage Tanks

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    Currently over 100 underground tanks at the Hanford facility in eastern Washington state are being used to store high-level radioactive waste. With plans for a long-term nuclear-waste repository in Nevada in place (though not yet approved), one promising use for these underground storage tanks is as a temporary waystation for waste destined for the Nevada repository. However, without a reasonable understanding of the chemical reactions going on within the tanks, transporting waste in and out of the tanks has been deemed to be unsafe. One hazard associated with such storage mechanisms is explosion of flammable gases produced within the tank. Within many of the storage tanks is a sludge layer. This layer, which is a mixture of liquid and solids, contains most of the radioactive material. Radioactive decay and its associated heat can produce several flammable materials within this layer. Two components of particular concern are hydrogen (H2) and nitrous oxide (N2O), since they are highly volatile in the gaseous phase. Though the tanks have either forced or natural convection systems to vent these gases, the possibility of an explosion still exists. Measurements of these gases are taken in several ways. Continuous measurements are taken in the headspace, which is the layer between the tank ceiling and the liquid (supernatant) or sludge layer below. In tanks where a supernatant layer sits atop the sludge layer, there are often rollovers or gas release events (GREs), where a large chunk of sludge, after attaining a certain void fraction, becomes buoyant, rising through the supernatant and releasing its associated gas composition to the headspace. Such changes trigger a sensor, and thus measurements are also taken at that time. Lastly, a retained gas sample (RGS) can be taken from either the supernatant or sludge layer. Such a core sample is quite expensive, but can yield crucial data about the way gases are being produced in the sludge and convected through the supernatant. Unfortunately, the measurements from these three populations do not seem to match. In particular, the ratio r = [N2O]/[H2] varies from population to population. r also varies from tank to tank, but this can more readily be explained in terms of the waste composition of each tank. Since H2 is more volatile than N2O (and since there are more sources of oxygen in the headspace), lower values of r correspond to more hazardous situations. This variance in r is troubling, since we need to be able to explain why certain values of r are lower (and hence more dangerous) in certain areas of the tank. In this report we examine the data from three tanks. We first verify that the differences in r among populations is significant. We then postulate several mechanisms which could explain such a difference

    Periodic Bouncing Modes for Two Uniformly Magnetized Spheres. I. Trajectories

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    We consider a uniformly magnetized sphere that moves without friction in a plane in response to the field of a second, identical, fixed sphere, making elastic hard-sphere collisions with this sphere. We seek periodic solutions to the associated nonlinear equations of motion. We find closed-form mathematical solutions for small-amplitude modes and use these to characterize and validate our large-amplitude modes, which we find numerically. Our Runge-Kutta integration approach allows us to find 1243 distinct periodic modes with the free sphere located initially at its stable equilibrium position. Each of these modes bifurcates from the finite-amplitude radial bouncing mode with infinitesimal-amplitude angular motion and supports a family of states with increasing amounts of angular motion. These states offer a rich variety of behaviors and beautiful, symmetric trajectories, including states with up to 157 collisions and 580 angular oscillations per period. A vibrant online learning community shares information about building beautiful sculptures from collections of small neodymium magnet spheres, with YouTube tutorial videos attracting over a hundred million views.1,2 These spheres offer engaging hands-on exposure to principles of magnetism and are used both in and out of the classroom to teach principles of mathematics, physics, chemistry, biology, and engineering.3 We showed recently that the forces and torques between two uniformly magnetized spheres are identical to the forces and torques between two point magnetic dipoles. In this paper, we exploit this equivalence to study the conservative nonlinear dynamics of a uniformly magnetized sphere subject to the magnetic forces and torques produced by a second, fixed, uniformly magnetized sphere, assuming frictionless hard-sphere elastic collisions between them. Our search for periodic states uncovers a wide variety of periodic modes, some of which are highly complex and beautiful

    Periodic Bouncing Modes for Two Uniformly Magnetized Spheres. II. Scaling

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    A uniformly magnetized sphere moves without friction in a plane in response to the field of a second, identical, fixed sphere and makes elastic hard-sphere collisions with this sphere. Numerical simulations of the threshold energies and periods of periodic finite-amplitude nonlinear bouncing modes agree with small-amplitude closed-form mathematical results, which are used to identify scaling parameters that govern the entire amplitude range, including power-law scaling at large amplitudes. Scaling parameters are combinations of the bouncing number, the rocking number, the phase, and numerical factors. Discontinuities in the scaling functions are found when viewing the threshold energy and period as separate functions of the scaling parameters, for which large-amplitude scaling exponents are obtained from fits to the data. These discontinuities disappear when the threshold energy is viewed as a function of the threshold period, for which the large-amplitude scaling exponent is obtained analytically and for which scaling applies to both in-phase and out-of-phase modes. The purpose of this work is to investigate the scaling relationships between the threshold energy, the threshold period, the bouncing number, the rocking number, and the phase of 1497 periodic modes found previously for the motion of a uniformly magnetized sphere subject to the field of a second, identical, fixed sphere. This large dataset offers the opportunity to identify scaling relationships to high precision for this highly nonlinear problem. Such scaling relationships recall techniques used in studying phase transitions and fractals and invite the search for universal scaling laws that may also apply to other systems. This work is motivated by our interest in the properties of collections of small neodymium magnet spheres that are used to create beautiful magnetic sculptures and are used both in and out of the classroom to teach principles of mathematics, physics, chemistry, biology, and engineering

    Building user commitment to implementing a knowledge management strategy

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    In the IS literature, commitment is typically considered to involve organizational or managerial support for a system and not that of its users. This paper however reports on a field study involving 16 organizations that attempted to build user involvement in developing a knowledge management strategy by having them design it. Twenty-two IT-supported group workshops (involving 183 users) were run to develop action plans for better knowledge management that users would like to see implemented. Each workshop adopted the same problem structuring technique to assist group members develop a politically feasible action plan to which they were psychologically and emotionally dedicated. In addition to reviewing the problem structuring method, this paper provides qualitative insight into the factors a knowledge management strategy should have to encourage user commitment. © 2004 Elsevier B.V. All rights reserved

    DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML

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    <b>Background</b>. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors (DNMTi), 5-azacytidine (AzaC) and 5-aza-2’-deoxycytidine (Decitabine), benefit some MDS/AML patients. However, the role of DNMTi-induced DNA hypomethylation in regulation of gene expression in AML is unclear.<p></p> <b>Results. </b> We compared the effects of AzaC on DNA methylation and gene expression using whole-genome single-nucleotide bisulfite-sequencing (WGBS) and RNA-sequencing in OCI-AML3 (AML3) cells. For data analysis, we used an approach recently developed for discovery of differential patterns of DNA methylation associated with changes in gene expression, that is tailored to single-nucleotide bisulfite-sequencing data (Washington University Interpolated Methylation Signatures (WIMSi)). By this approach, a subset of genes upregulated by AzaC was found to be characterized by AzaC-induced signature methylation loss flanking the transcription start site. These genes are enriched for genes increased in methylation and decreased in expression in AML3 cells compared to normal hematopoietic stem and progenitor cells. Moreover, these genes are preferentially upregulated by Decitabine in human primary AML blasts, and control cell proliferation, death and development. <p></p> <b>Conclusions.</b> Our WGBS and WIMSi data analysis approach has identified a set of genes whose is methylation and silencing in AML is reversed by DNMTi. These genes are good candidates for direct regulation by DNMTi, and their reactivation by DNMTi may contribute to therapeutic activity. This study also demonstrates the ability of WIMSi to reveal relationships between DNA methylation and gene expression, based on single-nucleotide bisulfite-sequencing and RNA-seq data.<p></p&gt

    LES/RANS Simulation of a Supersonic Reacting Wall Jet

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    This work presents results from large-eddy / Reynolds-averaged Navier-Stokes (LES/RANS) simulations of the well-known Burrows-Kurkov supersonic reacting wall-jet experiment. Generally good agreement with experimental mole fraction, stagnation temperature, and Pitot pressure profiles is obtained for non-reactive mixing of the hydrogen jet with a non-vitiated air stream. A lifted flame, stabilized between 10 and 22 cm downstream of the hydrogen jet, is formed for hydrogen injected into a vitiated air stream. Flame stabilization occurs closer to the hydrogen injection location when a three-dimensional combustor geometry (with boundary layer development resolved on all walls) is considered. Volumetric expansion of the reactive shear layer is accompanied by the formation of large eddies which interact strongly with the reaction zone. Time averaged predictions of the reaction zone structure show an under-prediction of the peak water concentration and stagnation temperature, relative to experimental data and to results from a Reynolds-averaged Navier-Stokes calculation. If the experimental data can be considered as being accurate, this result indicates that the present LES/RANS method does not correctly capture the cascade of turbulence scales that should be resolvable on the present mesh. Instead, energy is concentrated in the very largest scales, which provide an over-mixing effect that excessively cools and strains the flame. Predictions improve with the use of a low-dissipation version of the baseline piecewise parabolic advection scheme, which captures the formation of smaller-scale structures superimposed on larger structures of the order of the shear-layer width

    Standardless, automated determination of Chlorine-35 by 35Cl nuclear magnetic resonance

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    A robust, fully automated, walk-up method is reported to quantify chloride in samples using 35Cl nuclear magnetic resonance. Minimal user input is required, no standards are acquired at the time of analysis; and the submission, acquisition, processing, and production of results are seamlessly integrated within existing software. The method demonstrated good linearity with R2 = 0.999 over three orders of magnitude of analyte concentration. The results were highly independent of analyte functionality, and the stability of instrument response was sufficient that analyses of additional standards were not required for a period of several months. At a nominal sample concentration of 10 mg/ml in D2O at 400 MHz, detection and quantitation limits of 0.1 and 0.5% (w/w) were achieved in a 1-h analysis time. Robust methodology was achieved by applying a rigorous approach to method development and validation to determine and evaluate fully the time- and sample-dependent factors that affect quantitation in these measurements
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